Simultaneous Spectrophotometric Estimation of Atorvastatin Calcium and Amlodipine Besylate in Tablet Dosage Forms
نویسندگان
چکیده
A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of atorvastatin calcium and amlodipine besylate in their combined dosage forms. The method was based on property of additivity of absorbances. The two wavelengths on amlodipine besylate curve were found out where it showed same absorbance, which were 257.4 and 360.0 nm. At 360.0 nm, amlodipine besylate showed some absorbance while atorvastatin calcium showed zero absorbance. Both the drugs gave absorbance at 257.4 nm. The method involved solving of an equation based on measurement of absorbances at two wavelengths 257.4 and 360.0 nm. The proposed method was found to be simple, economical, accurate and reproducible for the routine analysis of both drugs in tablet dosage forms.
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